WIKIPEDIA
- Rae Sabine
- Aug 2
- 1 min read
WIKIPEDIA by Rae Sabine
Ankylosing spondylitis
Ankylosing spondylitis.
A type of arthritis.
Disease spectrum.
Axial spondyloarthritis.
Ankylos meaning
crooked,
curved,
rounded.
Spondylos meaning
vertebra.
-itis meaning
inflammation.
Long term inflammation
of the joints of the spine,
where the spine joins the pelvis.
Lower back pain,
hallmark.
Eye and gastrointestinal problems.
Arthritis of other joints.
Joint mobility
worsens over time.
Progression of symptoms.
Ankylosing spondylitis
involves a combination
of genetic and environmental factors.
Have a specific human leukocyte antigen,
the HLA-B27 antigen.
Genetic correlation varies across populations.
AS patients are HLA-B27.
Underlying mechanism
believed to be autoimmune
or autoinflammatory.
Diagnosis.
Symptoms.
From medical imaging.
Blood tests.
AS is a seronegative spondyloarthropathy.
Meaning that tests show no presence of rheumatoid factor antibodies.
There is no cure.
Treatments.
Medication.
Physical therapy.
Surgery.
The pain.
Symptoms of AS.
The disease progression.
Long term inflammatory processes.
Commonly used medications:
NSAIDs.
TNF inhibitors.
IL-17 antagonists.
DMARDs.
Glucocorticoid injections.
Acute localised flare-ups.
Bekhterev’s disease.
Bechterew’s disease.
Morbus Bechterew.
Bekhterev–Strümpell–Marie disease.
Marie’s disease.
Marie–Strümpell arthritis.
Pierre-Marie’s disease.
A 6th century skeleton
showing fused vertebrae,
severe ankylosing spondylitis.
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